Can Inositol Benefit Those With Type 2 Diabetes?

We have been recommending inositol to women with PCOS for years at the PCOS Nutrition Center. And for good reason: A combination of myo and d-chiro inositol (Ovasitol) have been shown to reduce insulin resistance and gestational diabetes, and inositol helps to improve fertility by improving egg quality and ovulation.

I saw the benefits of taking inositol firsthand after researching the published studies about it. As a woman with PCOS, I took metformin for years along with making changes to my lifestyle. This kept my hemoglobin A1C (or Ha1c) at 5.4% (prediabetes is considered at 5.7% and diabetes at 7% or higher). I started taking 4 grams of myo inositol daily. Within 3 months of regular use, my Ha1c went down to 5.1%. I kept taking it and 3 months later (6 months of using inositol) my Ha1c went down to 4.9%. I was thrilled! Metformin never did that for me.

I’ve often been asked if inositol can help those suffering from type 2 diabetes. The answer was always, we don’t know because there were no studies at the time. Until now.

Inositol For Individuals With Type 2 Diabetes

In a small (20 people) pilot study published in the International Journal of Endocrinology, researchers looked at the metabolic effects of taking a combination of myo-inositol (550 mg) and d-chiro-inositol (13.8 mg), in male and female individuals with type 2 diabetes. Inositols were given in a 40:1 ratio to mimic the level seen in human tissues. Inositols were taken orally, twice a day, as an add-on supplement to their glucose-lowering drugs like metformin. Participants in the study also followed a low GI diet.

The results were exciting. After 3 months of use, individuals who took the combined dosage of inositol saw significant reductions in their fasting glucose (192.6 versus 160.9) and Ha1c levels (8.6% versus 7.7%).

None of the subjects reported any side effects of taking the inositols, even with their glucose-lowering medications.

The researchers were surprised by the Ha1c reduction of 1.0 to 1.5% in a short amount of time, stating the benefits of combining myo and d-chiro inositol can help to achieve glycemic control. The researchers concluded:

“As an effective insulin sensitizer, inositol could represent a possible alternative to metformin or pioglitazone that are typically used as insulin sensitizer glucose-lowering drugs, when their use is not possible (i.e., metformin intolerance, drugs contraindications).”

FREE shipping to US & Canada

While this study is only a pilot study, it provides encouraging results that a combination of myo and d-chiro inositol in a 40:1 ratio is a safe way to help regulate blood sugar levels in those suffering from type 2 diabetes in addition to their current diabetes medications. It’ll be interesting to see what future long-term randomized trials that use inositol in individuals with type 2 diabetes show.


Pintaudi B, Di Vieste G, Bonomo M.The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes. Int J Endocrinol. 2016;2016:9132052.

Have you seen improvements in your glucose or Ha1c levels by taking inositol? Share your experiences with us below.

Leave A Comment

Your email address will not be published. Required fields are marked *

Comments (4)
  • Elenas

    March 10, 2017 at 9:55 am

    Very interesting reading. For how long should you take inositol /ovasitol in order to see results ? If nothing happens in e.g. six months maybe not the right supplement for you.. Any thoughts ?

  • Angela Grassi

    March 10, 2017 at 2:35 pm

    Good question Elena! We recommend taking 2 to 4 grams of Ovasitol daily for 3 months. Things to look for are reduction in cravings, improved menstrual regularity, and a reduction in your Ha1c levels. Sometimes you may not see a difference, but your labs can tell a different story.

  • Betty

    July 16, 2017 at 5:56 pm

    Does this mean men with prediabetes could try taking ovasitol?

  • Angela Grassi

    July 26, 2017 at 8:13 am

    Yes, men can take ovasitol. It only contains myo and d-chiro inositol.

Get Our Free Guide To Eating Well With PCOS

+ Recipes and PCOS Nutrition Tips
PCOS Nutrition Center

Sign Up!

Get Our Free Guide To Eating Well With PCOS

+ Recipes and PCOS Nutrition Tips
PCOS Nutrition Center