Health Benefits of Coenzyme Q10 For PCOS
Emerging research is showing that coenzyme Q10 or CoQ10 may offer numerous benefits to women with PCOS, Coenzyme Q10 has been shown to be involved in improving fertility and pregnancy in women with PCOS. Newer research is showing the potential of Q10 to lower cholesterol and insulin levels as well. Here’s what to know about Coenzyme Q10 if you have PCOS.
What Is Coenzyme Q10
Conenzyme Q10, or simply CoQ10, is a vitamin-like compound and antioxidant which functions as a cofactor in numerous metabolic pathways, particularly in energy production (ATP for those of you that remember the Krebs Cycle). CoQ10 use is associated with reductions in blood pressure, cholesterol, and pre-eclampsia.
CoQ10 may also boost energy and enhance the immune system, provide migraine relief, and help with chronic fatigue syndrome. Taking a statin medication can deplete levels of CoQ10 requiring supplementation.
Reesearch has demonstrated that CoQ10 can help with infertility in men and women by improving sperm and egg quality.
Health Benefits of Coenzyme Q10
- Boost energy
- Enhance immune system
- Improve blood pressure
- Lower cholesterol
- Prevent cellular damage by fighting free radicals
- Reduce risk of pre-eclampsia
- Migraine relief
- Improve chronic fatigue syndrome
- Improve sperm and egg quality
- Improve enodmetrial thickness
- Improve pregnancy rates in clomid resistant women with PCOS
CoEnyme Q10 and PCOS: Insulin and Cholesterol
New research is showing that Coenzyme Q10 may be able to help lower cholesterol and insulin levels. In a randomized trial published in the Journal of Clinical Endocrinology, women with PCOS received CoQ10 (100 mg) daily while another group received a placebo. After 12 weeks, PCOS women who took the Coq10 saw significant reductions in glucose, insulin, and total and LDL cholesterol levels.
Coenzyme Q10 and Egg Quality
As the quality of a woman’s eggs declines as she ages, there is also an age-related decline in CoQ10 utilization. According to a study published in the Journal of Fertility and Sterility, “decreased energy production in oocytes with aging may be related to a deficiency of CoQ10.” Additionally, with time, eggs are exposed to more damaging oxidative stress due to free radicals. As an antioxidant, CoQ10 has been linked to improving egg quality and ovulation by repairing free radicals.
Several trials in mice have found that administration of CoQ10 resulted in a significant increase in ovulated eggs.
CoQ10, PCOS and Fertility
New research has showed that CoQ10 and clomiphene citrate in the treatment of clomiphene-citrate-resistant PCOS patients improves ovulation and pregnancy. A prospective randomized controlled trial published in Reproductive Biomedicine Online evaluated the effect of combined coenzyme Q10 and clomiphene citrate for ovulation induction in clomiphene-citrate-resistant women with PCOS. A total of 101 infertile women with PCOS were randomized either to combined CoQ10 and clomiphene citrate or to clomiphene citrate alone. Those who supplemented with CoQ10 saw more follicles and greater endometrial thickness. Ovulation occurred in 65.9% in the CoQ10 group compared with only 15.5% in the control group. Pregnancy rate was significantly higher in the CoQ10 group (37.3%) versus the control group (6.0%).
CoQ10 and Male Fertility
CoQ10 has been shown to help with male infertility by improving sperm quality and motility. A 2013 meta-analysis showed CoQ10 at 200 mg daily for 6 months significantly improved sperm motility. A preliminary clinical study showed that infertile men who took coenzyme CoQ10 at 300 mg daily had significantly improved sperm density and motility after 26 weeks of treatment compared with placebo.
Side Effects of CoQ10
Overall, CoQ10 is well tolerated. According to the Natural Medicines Comprehensive Database, CoQ10 has been safely used in studies lasting up to 30 months. CoQ10 may have blood pressure lowering effects; herbs or other supplements that can also lower blood pressure should be used with caution.
How Much To Take?
Diet sources of CoQ10 include meats and seafood. However, the amounts eaten in foods do not approach therapeutic doses of 200 mg to 600 mg daily. Ubiquinol is the form of CoQ10 that absorbed and utilized best.
Coenzyme Q10 taken 100 mg twice daily has been safely used during pregnancy, starting at 20 weeks gestation until birth. CoQ10 is fat soluble and should be taken with a meal containing fat.
Coenzyme Q10 offers potential to help women with PCOS lower cholesterol and insulin. CoQ10 is a safe and effective option for improving fertility and pregnancy in clomiphene-citrate-resistant PCOS women. CoQ10 may benefit men struggling with infertility by improving semen quality and motility. While animal studies show benefits of CoQ10 in supplying energy and functioning as an antioxidant for aging eggs, more well controlled randomized trials in women are needed. In addition to CoQ10, women who are older may also be interested in myo-inositol and NAC, which have also been shown in studies to improve egg quality in women with PCOS.
Tell us! What has been your experience with CoQ10? Did it help you get pregnant?
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