Health Benefits of Coenzyme Q10 For PCOS

Emerging research is showing that coenzyme Q10 or CoQ10 may offer numerous benefits to women with PCOS,  Coenzyme Q10 has been shown to be involved in improving fertility and pregnancy in women with PCOS. Newer research is showing the potential of Q10 to lower cholesterol and insulin levels as well. Here’s what to know about Coenzyme Q10 if you have PCOS.

What Is Coenzyme Q10

Conenzyme Q10, or simply CoQ10, is a vitamin-like compound and antioxidant which functions as a cofactor in numerous metabolic pathways, particularly in energy production (ATP for those of you that remember the Krebs Cycle). CoQ10 use is associated with reductions in blood pressure, cholesterol, and pre-eclampsia.

CoQ10 may also boost energy and enhance the immune system, provide migraine relief, and help with chronic fatigue syndrome. Taking a statin medication can deplete levels of CoQ10 requiring supplementation.

Reesearch has demonstrated that CoQ10 can help with infertility in men and women by improving sperm and egg quality.

Health Benefits of Coenzyme Q10

  • Boost energy
  • Enhance immune system
  • Improve blood pressure
  • Lower cholesterol
  • Prevent cellular damage by fighting free radicals
  • Reduce risk of pre-eclampsia
  • Migraine relief
  • Improve chronic fatigue syndrome
  • Improve sperm and egg quality
  • Improve enodmetrial thickness
  • Improve pregnancy rates in clomid resistant women with PCOS

CoEnyme Q10 and PCOS: Insulin and Cholesterol

New research is showing that Coenzyme Q10 may be able to help lower cholesterol and insulin levels. In a randomized trial published in the Journal of Clinical Endocrinology, women with PCOS received CoQ10 (100 mg) daily while another group received a placebo. After 12 weeks, PCOS women who took the Coq10 saw significant reductions in glucose, insulin, and total and LDL cholesterol levels.

pcos supplement quiz

Coenzyme Q10 and Egg Quality

As the quality of a woman’s eggs declines as she ages, there is also an age-related decline in CoQ10 utilization. According to a study published in the Journal of Fertility and Sterility, “decreased energy production in oocytes with aging may be related to a deficiency of CoQ10.” Additionally, with time, eggs are exposed to more damaging oxidative stress due to free radicals. As an antioxidant, CoQ10 has been linked to improving egg quality and ovulation by repairing free radicals.

Several trials in mice have found that administration of CoQ10 resulted in a significant increase in ovulated eggs.

CoQ10, PCOS and Fertility

New research has showed that CoQ10 and clomiphene citrate in the treatment of clomiphene-citrate-resistant PCOS patients improves ovulation and pregnancy. A prospective randomized controlled trial published in Reproductive Biomedicine Online evaluated the effect of combined coenzyme Q10 and clomiphene citrate for ovulation induction in clomiphene-citrate-resistant women with PCOS. A total of 101 infertile women with PCOS were randomized either to combined CoQ10 and clomiphene citrate or to clomiphene citrate alone. Those who supplemented with CoQ10 saw more follicles and greater endometrial thickness. Ovulation occurred in 65.9% in the CoQ10 group compared with only 15.5% in the control group. Pregnancy rate was significantly higher in the CoQ10 group (37.3%) versus the control group (6.0%).

CoQ10 and Male Fertility

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CoQ10 has been shown to help with male infertility by improving sperm quality and motility. A 2013 meta-analysis showed CoQ10 at 200 mg daily for 6 months significantly improved sperm motility. A preliminary clinical study showed that infertile men who took coenzyme CoQ10 at 300 mg daily had significantly improved sperm density and motility after 26 weeks of treatment compared with placebo.

Side Effects of CoQ10

Overall, CoQ10 is well tolerated. According to the Natural Medicines Comprehensive Database, CoQ10 has been safely used in studies lasting up to 30 months. CoQ10 may have blood pressure lowering effects; herbs or other supplements that can also lower blood pressure should be used with caution.

How Much To Take?

Diet sources of CoQ10 include meats and seafood. However, the amounts eaten in foods do not approach therapeutic doses of 200 mg to 600 mg daily. Ubiquinol is the form of CoQ10 that absorbed and utilized best.

pcos Co!0

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Coenzyme Q10 taken 100 mg twice daily has been safely used during pregnancy, starting at 20 weeks gestation until birth. CoQ10 is fat soluble and should be taken with a meal containing fat.

Bottom Line

Coenzyme Q10 offers potential to help women with PCOS lower cholesterol and insulin. CoQ10 is a safe and effective option for improving fertility and pregnancy in clomiphene-citrate-resistant PCOS women.  CoQ10 may benefit men struggling with infertility by improving semen quality and motility. While animal studies show benefits of CoQ10 in supplying energy and functioning as an antioxidant for aging eggs, more well controlled randomized trials in women are needed. In addition to CoQ10, women who are older may also be interested in myo-inositol and NAC, which have also been shown in studies to improve egg quality in women with PCOS.

Tell us! What has been your experience with CoQ10? Did it help you get pregnant? 


Samimi, M., Zarezade Mehrizi, M., Foroozanfard, F., et al.  The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Endocrinol.2017.
El Refaeey A, Selem A, Badawy A.Combined coenzyme Q10 and clomiphene citrate for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome.Reprod Biomed Online. 2014 Jul;29(1):119-24.

Bentov Y, Casper RF.The aging oocyte–can mitochondrial function be improved? Fertil Steril. 2013 Jan;99(1):18-22.

Burstein E, Perumalsamy A, Bentov Y, Esfandiari N, Jurisicova A, Casper RF. Co-enzyme q10 supplementation improves ovarian response and mitochondrial function in aged mice [abstract]. Fertil Steril. 2009;92(Suppl):S31

Lafuente R, González-Comadrán M, Solà I, López G, Brassesco M, Carreras R, Checa MA.Coenzyme Q10 and male infertility: a meta-analysis. J Assist Reprod Genet. 2013 Sep;30(9):1147-56.

Safarinejad MR, Safarinejad S, Shafiei N et al: Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. J Urol 2012; 188: 526.

Teran E, Hernandez I, Nieto B, et al. Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia. Int J Gynaecol Obstet 2009;105:43-5.

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Comments (7)
  • Patricia

    February 22, 2017 at 8:57 am

    I know the coenzyme q10 work wonders on the skin but I didn’t expect it would also be one treatment for pcos. I don’t have one but I know friends who were diagnosed with the said disease and I know they are struggling to maintain their normal weight and struggles to have a regular menstrual flow.

    I will definitely share this article and new knowledge to my friends who are currently managing their pcos. This is such a great help and I am glad I came across your blog! This is definitely an article that’s one for the books!

  • Mary Cawthorne

    March 24, 2017 at 1:21 am

    I started taking this because of the article. And it’s been SO GREAT. As much as I don’t want to admit, I was depressed and it helped my depression so much. My boyfriend was taken back by my new energy (I didn’t tell him that I had recently taken a new supplement until later). I bought the gummy supplements from CVS just for starters. And I’m really happy. I definitely suggest it. Has had better effect than me taking ovasitol for over a year.

  • Mary Cawthorne

    March 24, 2017 at 1:22 am

    *no effects on regulating periods on either for me personally

  • Laurika Gonzales

    November 30, 2018 at 9:49 am

    So this is a food supplement.. Can this be bought over the counter? Without any prescription?

  • Angela Grassi

    December 20, 2018 at 5:57 pm

    yes, it is a dietary supplement and is sold over the counter.

  • Amanda

    April 2, 2019 at 8:17 pm

    Can this be taken with ovasitol? I have taken ovasitol for years and swear by it for helping my energy and sugar cravings. I still have very irregular or non existent cycles so I’d like to add to my ovasitol if it is ok to.

  • Angela Grassi

    April 3, 2019 at 7:43 am

    Yes you can take CoQ10 with Ovasitol. Very important to take Q10 if you also take a statin.

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