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Myo-Inositol Proves Better for Fertility than d-Chiro-Inositol

Myo-Inositol Proves Better for Fertility than d-Chiro-Inositol

Inositol is a member of the B-vitamins and a component of the cell membrane. There are several forms of inositol with myo-inositol or d-chiro-inositol showing therapeutic value. The body converts d-chiro inositol from myo-inositol. There are many reasons women with PCOS may want to take this supplement as inositol has been linked to improved insulin, triglyceride and testosterone levels, as well as improved blood pressure, ovulation and weight loss.

PCOS & inositol

Only a handful of studies were conducted on myo and d-chiro-inositol and PCOS, all showing favorable results. It is believed that inositol increases the action of insulin in women with PCOS, thereby improving ovulation, decreasing testosterone, and lowering blood pressure and triglycerides. Another showed that myo-inositol may prevent gestational diabetes in PCOS women.

Infertility and inositol

While d-chiro-inositol has been shown to be effective at improving insulin, myo-inositol, its predecessor, is showing to be more effective at improving fertility.

A study published this past April in the European Review Medical Pharmacology examined the effects of both forms of inositol in women undergoing fertility treatments. One group received 2g of myo-inositol twice daily and a second group with .6g of d-chiro-inositol twice daily. The results: Women who received myo-inositol had better quality and more mature eggs. They also had more pregnancies than those who took d-chiro- inositol.

Because d-chiro-inositol gets made from myo-inositol, researchers speculate that supplementing with myo-inositol may improve levels of both forms-at least in regards to fertility.

Some points to consider regarding this study:

  • This study did not involve women with PCOS who were trying to conceive.
  • The participants also had controlled insulin levels at the start.
  • This study focused on infertility aspects of only egg quality and development.
  • The brand of myo-inositol used in the study, INOFOLIC, is not available in the United States
  • Lack of other evidence. More studies that compare the effectiveness of myo vs. d-chiro-inositol are needed.

Bottom line: based on the current evidence, if you are trying to conceive, you might want to try myo-inositol. If you are looking to lose weight and improve insulin, d-chiro-inositol may still be your best bet.

For more information on inositol including dosage and side effects in PCOS click here.

Danna R. DiBenedetto V, Rizzo P. Myo-inositol may prevent gestational diabetes in PCOS women. Gynecol Endocrinol. 2011.

Carlomagno G, Unfer V, Roseff S. The D-chiro-inositol paradox in the ovary. Fertil Steril.
2011;95(8):2515-6.

Unfer V, Carlomagno G, Rizzon P, Raffone E, Roseff S. Myo-inositol rather than D-chiro-inositol is
able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective,
controlled, randomized trial. Eur Rev Med Pharmacol Sci 2011;15(4):452-7.

Galazis N, Galazi M, Atiomo W. d-Chiro-inositol and its significance in polycystic ovary syndrome:
a systematic review. Gynecol Endocrinol. 2011;27(4):256-62

Papaleo, E., Unfer, V., Baillargeon, J.P., et al. (2007). Myo-inositol in patients with polycystic
ovary syndrome: A novel method for ovulation induction. Gynecological Endrocrinology,23 (12):
700-703.

Nestler J, Jakubowicz DJ, Reamer P, Gunn R. Ovulatiory and metabolic effects of D-Chiro- Inositol
in the polycystic ovary syndrome. New Eng J Med 1999;340(17):1314-1320.
Copyright ©

Has inositol helped you? Let us know. What form and how?

COMMENTS (7)

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I am taking both myo-inositol and DCI.

With myo-inositol I have experienced elevated mood. I had difficulty sleeping for 25 years after my hysterectomy, after starting myo-inositol I now get a restful full-night's sleep with pleasnt colorful dreams. It impacts serotonin levels leading to the sleep improvement. I took d-pinitol for awhile, but switched to DCI - which is now less expensive, and women with PCOS supposedly have difficulties converting d-pinitol to DCI, so I figured I was better off going the direct route. DCI has significantly redistributed my weight - in particular from my upper abdomen, upper arms, and my neck. People have commented on the dramatic results. It has also ended the horrible fatigue I had experienced my whole life- it has given me back my life. Suppposedly, DCI reverses fatty liver disease, with which I had been diagnosed. Humorously, it has given me something I had never experienced before - orgasms that wake me from my sleep at night. It has stopped the constant nausea after eating anything other than very bland food. I am thrilled with the results of both myo-inositol and DCI. The excess hair on my face has lessened and is finer, too.

Posted by: Sharon | August 11, 2011, 11:08 am

My comment goes specifically to women out there with PCOS and TTC. It is not intended for anyone that does not meet these criteria. Thank you!

There are a few things about this article that make me hesitant:


• One group received 2g of myo-inositol twice daily and a second group with .6g of d-chiro-inositol twice daily.

• This study did not involve women with PCOS who were trying to conceive.

• The participants also had controlled insulin levels at the start.

• This study focused on infertility aspects of only egg quality and development.

• The brand of myo-inositol used in the study, INOFOLIC, is not available in the United States

• Lack of other evidence. More studies that compare the effectiveness of myo vs. d-chiro-inositol are needed.


1. I do not understand why the myo-inositol group was given more than the DCI group. This seems to unfairly favor the results of the myo group from the very beginning and therefore making a false experiment.

2. The article clearly states that the case did NOT involve women with PCOS that were TTC. It is a little confusing at first because there is a little blurb in the article about PCOS and TTC. But if you re-read it you will see that it clearly said the DCI proved to benefit women with PCOS and TTC. It never mentions the effect of myo on women with PCOS. This is a marketing scheme that really upsets me. They know that most women with PCOS will only remember “that article mentioned something about PCOS and the effects of myo-inositol.” This causes more false-hope, more money out of our pockets, and all for them to make a profit. They pry off the hope we have to find something that works and know that we will try anything to get pregnant so they trick us by bringing us into an article that has nothing to do with us.

3. Everyone in this experiment had controlled levels of insulin. Since we have PCOS our insulin levels are not controlled. Therefore, we cannot trust the results of this experiment would have the same effects on us. They would have to do another study on the same experiment on women with uncontrolled levels of insulin (with positive results) for most of us to consider this treatment.

4. The women in the experiment had infertility due to poor egg quality/development, NOT PCOS. Therefore, the only thing this experiment “proved” was that myo-inositol MAY be better for women TTC that have infertility due to poor egg development/quality and not PCOS.

5. The brand they used in the experiment is not even available in the USA. Therefore, if you try this yourself you will have to find a different brand that has never been tested. Or, pay more money to somehow get your hands on this supplement overseas.

6. It clearly states that there is a LACK OF EVIDENCE from this experiment and that it needs further testing to better support their findings.

I would not suggest women with PCOS to take myo-inositol alone in hopes of curing their PCOS. I believe it would be a waste of money and would not work. I know this article gets our hopes up, but it is very clearly written that this experiment was not including PCOS and TTC. What’s more is that it clearly DOES suggest that DCI (d-chiro-inositol) proves favorable for PCOS and TTC.

Now, that being said, it may be favorable for women with poor egg quality and PCOS to take both. My doctor has already said that my eggs look great and that is not ovulating due to PCOS that is the problem. Therefore, myo-inositol would not really matter much to me and it would just take my body longer to convert it into DCI. Anything that makes my body work harder at producing what it needs, in my own opinion, is going to be more time wasted. But everyone has to do what they think is best for them you know? This was just my opinion based on the evidence provided in the article. For some it may be enough to try it out but for me it will take much more research and experimentation on this treatment specifically for women like me to really consider trying it out.

Posted by: Kim | December 15, 2011, 12:00 pm

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