10 Surprising Benefits of Ovasitol for PCOS

Sure, you may have heard that the inositol supplement Ovasitol is great for PCOS, but not sure if you believe the hype? Here’s 10 benefits of taking Ovasitol if you have PCOS.

What is Ovasitol?

Ovasitol is a high quality, medical-grade supplement that combines both myo and d-chiro-inositol that mimic’s the body’s own ratio.

Inositol is a pseudovitamin of the B vitamin family, which is like saying, it’s almost a vitamin. It’s found in many foods such as fruit, vegetables, beans and buckwheat.


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Why Ovasitol?

Ovasitol has both myo- and D-chiro-inositol in the ideal 40 to 1 ratio to mimic levels in the body. This ideal ratio helps restore menstrual regularity and hormone balance, and aid in insulin signaling, thereby decreasing insulin resistance. This results in lower insulin and blood sugar levels better than myo inositol alone.

Ovasitol it is the first and only inositol supplement that has been independently verified for content accuracy, purity, and freedom from contaminants through a not-for-profit certification program (NSF® International). Ovasitol is formulated by an advisory board of leading reproductive health specialists.

Here are 10 benefits of taking Ovasitol if you have PCOS:

Improves Egg Quality

A major problem in PCOS is that people tend to produce many eggs, but the eggs are poor quality due to the hormone imbalance. A combination of Myo to d-chiro inositol in the ideal 40:1 ratio has been well documented to improve egg quality. High levels of d-chiro inositol (over 300 mg daily) has been shown to worsen egg quality. This is because the ovary contains a high levels of myo inositol. It is believed that women with PCOS have a defect leading to a rapid conversion of myo to d-chiro inositol, depleting levels of myo inositol.

Better Menstrual Regularity and Ovulation

The majority of women who take Ovasitol see more regularity with their menstrual cycles within 3 months. Many health care providers are now recommending patients with PCOS try Ovasitol before going on medications with side effects (looking at you metformin!). Ovasitol is particularly good for adolescents with PCOS who may not need oral contraceptives.

A review of 12 randomized control trials showed that using Myo-inositol in combination with D-chiro-Inositol is capable of restoring spontaneous ovulation and improving fertility in women with PCOS.

Reduces Cravings

I haven’t seen any published evidence to show this, but I have heard from the majority of patients who take Ovasitol (as well as myself!), that it lowers their cravings for carbohydrates and sweets. As one woman put it “It makes me feel like a normal person.” This reduction in cravings could be due to the power of Ovasitol to lower the appetite stimulating insulin (see below).

Lowers Insulin and Glucose

Inositols work by helping the body use insulin more effectively.  They are considered “secondary messengers” in insulin signaling.  Insulin is a hormone made by the pancreas that allows our cells to take in glucose and produce energy from the food we eat.  For insulin to work, it must bind to the insulin receptor on the surface of our cells.

Think of a lock (the insulin receptor) and a key (insulin).  When insulin binds to its receptor, it “unlocks” and releases secondary messengers.  These secondary messengers tell the cell it is time to take in glucose from the blood.

Most women with PCOS are insulin resistant and do not properly release secondary messengers (such as inositol).  As a result, glucose does not get into the cell efficiently, and blood sugar levels remain high.  This tells the pancreas to make more insulin.  The over-production of insulin results in high insulin and blood sugar levels.

Check out this video where I explain inositol’s actions in PCOS: VIDEO LINK

Improves Diabetes

Because Ovasitol has been shown to lower glucose and insulin in PCOS, researchers are now studying it in those with diabetes.  Some research has shown that taking inositol can improve blood sugar levels in those with type 2 diabetes. 

Helps with Mood

Inositol has been shown to improve both anxiety and depression. Sixty women with PCOS were randomly assigned to intake either myo-inositol or metformin for 12 weeks. Mental health indicators significantly improved in the myo-inositol group compared to the metformin group.

A review of seven studies found that inositol significantly reduced depression compared to placebo, especially well for those with PMDD.

ovasitol for PCOS

Decreases Cholesterol

The combined therapy myo-inositol plus D-chiro-inositol (in a in a physiological ratio of 40:1) has been shown to improve cholesterol levels. PCOS patients who took the combined therapy of myo-inositol plus D-chiro-inositol showed significant reductions in LDL (the “bad” cholesterol) and triglyceride levels in just 6 months.

Lowers Androgen Levels

Another added benefit of Ovasitol is that it has the ability to lower androgen (testosterone) levels. PCOS patients who took inositol showed significant reductions in androgen levels in just 6 months of use

Improves Thyroid Functioning

Myo-inositol plays an important role in thyroid function and autoimmunity. Clinical studies have shown that after treatment with Myo-inositol, TSH levels significantly declined in patients with subclinical hypothyroidism as well as a decline of antithyroid autoantibodies.


Reduces Gestational Diabetes Risk

Women with PCOS are at an increased risk for developing gestational diabetes. Numerous studies have found that inositols decrease the risk of gestational diabetes during pregnancy.

A 40:1 combination of myo-inositol, D-chiro-inositol, and other nutrients decreased the risk of gestational diabetes among women with elevated first trimester fasting blood sugar levels.

A study of women with PCOS found that only 17% of those who took myo-inositol throughout pregnancy developed gestational diabetes (compared to 54% of those who did not take inositol).  Studies also found that myo-inositol decreased the risk of gestational diabetes by 50-67% among women with a family history of type 2 diabetes.

Are There Side Effects From Ovasitol?

There are no expected side effects from Ovasitol. Studies have shown that inositol is safe and well-tolerated when taken at the typical recommended dose of 4,000 mg a day. Ovasitol can be taken along with most other nutritional supplements and prescription medications, including metformin. Ovasitol is safe to continue throughout pregnancy. As with any dietary supplement, it is important to discuss the use of all medications, vitamins and supplements with your healthcare team.

What Is The Recommended Dosage Of Ovasitol?

The recommended dosage of Ovasitol is one packet, twice a day. Ovasitol is packaged in a convenient, single-serving packet to empty into water or other beverage. Each packet contains a tasteless and odorless gluten-free powder, with 2,000 mg of myo-inositol + 50 mg of D-chiro-inositol. One box of Ovasitol contains 180 packets and is designed to last 90 days. It generally takes at least three months of daily inositol supplementation to see improvement in your test results and/or the return of regular menstrual cycles.

Read Frequently asked questions about Ovasitol

Where Do you Buy Ovasitol?

Ovasitol is available at the lowest price in the PCOS Nutrition Center Store with free shipping to US and Canada.

Ovasitol for PCOS


Akbari Sene A1, Tabatabaie A1, Nikniaz HThe myo-inositol effect on the oocyte quality and fertilization rate among women with polycystic ovary syndrome undergoing assisted reproductive technology cycles: a randomized clinical trial. Arch Gynecol Obstet. 2019 Jun;299(6):1701-1707.

Minozzi M, Nordio M, Pajalich R. The Combined therapy myo-inositol plus D-Chiro-inositol, in a physiological ratio, reduces the cardiovascular risk by improving the lipid profile in PCOS patients. Eur Rev Med Pharmacol Sci. 2013 Feb;17(4):537-40.

Fallahi P, Ferrari SM, Elia G. Myo-inositol in autoimmune thyroiditis, and hypothyroidism. Rev Endocr Metab Disord. 2018 Dec;19(4):349-354.

Jamilian H, Jamilian M2, Foroozanfard FComparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. J Psychosom Obstet Gynaecol. 2018 Dec;39(4):307-314.

Mukai T, Kishi T, Matsuda Y. A meta-analysis of inositol for depression and anxiety disorders. Hum Psychopharmacol. 2014 Jan;29(1):55-63.

D’Anna et al. Myo-inositol may prevent gestational diabetes in PCOS women. Gynecol Endocrinol. 2012; 28(6):440-2.

Dell’ Edera et al. The influence of D-chiro-inositol and D-myo-inositol in pregnant women with glucose intolerance. Biomed Rep. 2017; 7(2):169-172.

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Comments (33)
  • Pauline

    August 1, 2019 at 10:40 am

    How does this affect me if I’m 55 years old and don’t have periods anymore and don’t want to have them.

  • Angela Grassi

    August 12, 2019 at 4:57 pm

    Women who are no longer menstruating can take Ovasitol because it can still help with metabolic aspects like cholesterol and insulin resistance.

  • Caroline

    January 22, 2020 at 3:01 pm

    Hi, I have PCOS and a history of gestational diabetes with my first pregnancy and am currently pregnant with my second child. I just ordered ovasitol from your website. When should I take ovasitol? Now to prevent GD? Or after I’m diagnosed?

  • Angela Grassi

    January 23, 2020 at 9:26 am

    Hi Caroline,
    Best to take Ovasitol as soon as possible in your pregnancy to prevent gestational diabetes. Let us know how it helps you! Here are some additional tips to help prevent gestational diabetes: https://www.pcosnutrition.com/inositols-decrease-gestational-diabetes-pcos-women/


  • Caroline

    February 23, 2020 at 3:14 pm

    Hi again, I’ve been taking the Ovasitol since about 21 weeks but at 24 weeks I was diagnosed with GD again. Should I continue taking it? If I need to take other medications for the GD, would I still take the ovasitol?

  • Angela Grassi

    February 24, 2020 at 11:05 am

    There is evidence that inositol can reduce the risk for gestational diabetes. we aren’t sure about how it works to treat it. I would discuss with your doctor about its benefits.

  • Joanna

    July 23, 2020 at 3:43 am

    Hi im joanna from Philippines. I’m 32 yo and have Pcos.i want to try this ovasitol, can you ship here in Philippines?., pls help me

  • Angela Grassi

    August 7, 2020 at 2:52 pm

    No, sorry. We only ship Ovasitol to the USA and Canada

  • Hiral

    September 2, 2020 at 5:33 pm

    Hello there. I have hormonal imbalance and have very high testosterone in my body and low estrogen. Does this help with reducing testosterone? Also do you ship to Switzerland

  • Angela Grassi

    September 3, 2020 at 10:45 am

    Yes, this can help reduce testosterone levels. We do not ship to Switzerland but you can find Ovasitol there.


    December 6, 2020 at 1:32 pm

    I want in india plz tell the prize and availability in India

  • Angela Grassi

    December 31, 2020 at 10:24 am

    Sorry, we only ship to USA and Canada.

  • Anih Ifeanyichukwu

    April 13, 2021 at 7:56 am

    Thanks for this info

  • Elizaveta

    May 3, 2021 at 10:44 am

    Hi! Can I take Ovasitol + Metformin + Prenatal?
    Thank you

  • Angela Grassi

    May 4, 2021 at 9:59 am

    Yes they can be taken together.

  • Gaurisha

    May 25, 2021 at 9:08 pm

    Hi, I was diagnosed with pcod and hypothyroid last year in August. I missed my periods for a month and since then I am getting regular periods. I am not taking any pcod or thyroid medication. But I have weight issues and extreme sugar cravings all day. Should I consider taking ovasitol even while being on regular menstruation?

  • Angela Grassi

    June 12, 2021 at 2:52 pm

    Yes! Many women with regular periods find Ovasitol can help reduce sugar cravings.

  • Anmol

    July 5, 2021 at 4:01 am

    Hey is it safe to take ovaistol when you’re already taking some medicine like proactive pcos tabelts and some multivitamin if yes pls guide me through this

  • Angela Grassi

    July 26, 2021 at 2:13 pm

    Ovasitol can be taken safely with other vitamins and minerals.

  • Alejandra Ramirez

    July 17, 2021 at 7:15 pm

    I have PCOS and I got the mirena iud, can I still continue to take this?

  • Angela Grassi

    July 26, 2021 at 2:12 pm

    Ovasitol will not interfere with IUD

  • Erika

    August 14, 2021 at 12:55 am

    I accidentally took 3 packages today ! Thinking it was 1 in each meal is this bad ?? I’m worried …..

  • Melissa Coleman

    August 15, 2021 at 10:27 pm

    Hello, I do not have sugar issues and am very thin but do have Pcos. My only symptom from pcos is I don’t ovulate regularly and my hormones are out of whack. Who ovistrol help me? Can I hurt me?

  • Angela Grassi

    August 16, 2021 at 7:32 am

    Ovasitol helps to promote menstrual regularity and hormone balance. it is safe.

  • Vanessa

    September 26, 2021 at 2:50 am

    Is it safe to take this while receiving the depo shot as my form of birth control?

  • Angela Grassi

    October 3, 2021 at 2:16 pm

    Yes, it will not affect it.

  • Erin Breen

    September 14, 2022 at 2:53 pm

    I have a mirena coil fitted to help manage endometriosis symptoms and act as a contraceptive. Will taking Ovasitol effect the coil in any way?

  • Angela Grassi

    October 5, 2022 at 10:14 am

    no, it should not.

  • Cynthia

    May 16, 2023 at 9:27 pm

    Those Ovasitol tablet and powder same or are there different, and which one is more effective. Can it be shipped to Australia

  • Angela Grassi

    June 1, 2023 at 12:16 pm

    Ovasitol is only a powder form. We don’t directly ship to Australia but you can get it shipped this way:

    Here is how:
    Step 1: Create a FREE account on Stackry here (there is a fee that varies between countries)
    Step 2: Receive your US-based shipping address
    Step 3: Go to our checkout page and enter with your US-based shipping address
    Step 4: Stackry will provide you with a tracking # so you can track your supplement delivery!

  • Santina victor

    January 19, 2024 at 10:06 pm

    J’avais des ovaires politiques j’aimerais achte

  • Kayla Z

    January 22, 2024 at 1:18 pm

    I just started using this just to improve overall health as I am trying to get pregnant. I do not have PCOS but i do have hypothyroidism.
    My periods have always been regular. I am wondering if I just started taking this, if it throws off regularity of my periods or will it remain the same.

  • Angela

    February 7, 2024 at 3:51 pm

    No, Ovasitol should not change your cycle.

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