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The PCOS Nutrition Center Resveratrol Protect combines two powerful antioxidants, resveratrol and quercetin, to offer maximum protection to combat free radicals and help reduce the impact of their damage on the aging process.* In people with PCOS, Resveratrol Protect may help to reduce inflammation and androgens, and improve insulin sensitivity and egg quality. Resveratrol Protect contains the polyphenol resveratrol, which is found in peanuts, berries, red grape skins, and red wine and quercertin, a flavonoid found in red onions, apples, olive oil, dark berries and herbs that provides anti-inflammatory benefits.* The synergy between resveratrol and quercetin are more powerful together than taken alone.

Recommended Use: Take 1 capsule per day or as directed by your health-care practitioner.

Non-GMO, Gluten Free, Dairy Free Soy Free, Vegan


SKU: resveratrolS Category:

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The PCOS Nutrition Center Resveratrol Protect is an exciting combination of two powerful antioxidants, resveratrol and quercetin.

Resveratrol Protect may help support*:

Cardiovascular system*

Neurological health*

Healthy aging*

Glucose & insulin regulation*


Lowering adrenal & ovarian androgens*

Oocyte quality and maturation*

Menstrual regularity*

Damage from free radicals is a primary driver of compromised health, and this may particularly affect the cardiovascular system (blood vessels) and neurons—especially the neurons’ mitochondria, which are the parts of the cell that generate energy. Proper functioning of the mitochondria is crucial for overall health. Excessive oxidative damage (damage from free radicals) is also implicated in the aging process. Antioxidants combat free radicals and help reduce the impact of their damage.


Resveratrol is found in peanuts, berries, red wine (from the skin of red grapes), and in the Japanese knotweed plant, also known as Polygonum. Resveratrol is produced by certain plants to act as a natural pesticide, protecting the plant from environmental insults. In the case of grapes, it concentrates in the skin and protects the plant from mold and bacterial infection. The harsher the climate in which grapes grow, the more protection the grapes need, and therefore, wine produced from those grapes has a higher amount of resveratrol. Resveratrol may have a similar protective effect against natural physiological damage when consumed in the diet.

The resveratrol in this product has been standardized to all trans resveratrol, as the opposite or “cis” form may not have the same beneficial biological activity. It is also more highly concentrated,
to provide a greater amount of resveratrol than an individual would be likely to obtain through a reasonable diet.

Resveratrol and PCOS

In a triple-blind randomized control trial, 62 PCOS patients were randomly assigned to two groups. All patients took resveratrol 800 mg/day or placebo for 40 days orally from the beginning of their previous menstruation cycle until the oocyte retrieval day. A significant mean difference was seen in the FSH, LH, TSH, and testosterone between the two groups and the high-quality oocyte rate and high-quality embryo rate were higher in the resveratrol group.


A randomized double-blind, placebo-controlled trial found that resveratrol (1500 mg) over a period of 3 months led to a significant decrease of total testosterone by 23.1%,  a 22.2% decrease of dehydroepiandrosterone sulfate (DHEAS), a decrease of fasting insulin level by 31.8% and an increase of the insulin sensitivity index by 66.3%.


PCOS women, between 18-40 years, were randomized to either 1000 mg resveratrol or 1000 mg placebo for 3 months. At the end of the study, it was found that women who received resveratrol had a statistically higher regular menstruation rate, as compared to those who got placebo (76.47% vs. 51.61%), and lower hair loss (32.10% vs. 68.00%).


A similar study found resveratrol, as compared with placebo, was associated with a significantly higher rate of improvement in the ovarian morphology. Women who received resveratrol had a more dominant follicle than those getting placebo, with a significant reduction in the ovarian volume.



Quercetin has been called “king of the flavonoids” because of its powerful antioxidant properties and its ability to support a healthy inflammatory response in the body.* Quercetin is found in many foods such as red onions, apples, olive oil, dark berries and grapes, capers, salad greens, and culinary herbs such as dill, cilantro, watercress, and radicchio. (Quercetin contributes to the bold colors of these foods.) Laboratory studies show an anti-inflammatory effect of quercetin, including inhibition of histamine release which may make it helpful for allergy sufferers.


Quercetin and PCOS

A review of studies that used quercetin in PCOS patients, supported the beneficial effects of quercetin on the ovarian histomorphology, folliculogenesis, and luteinisation processes. The effects of quercetin on reducing the levels of testosterone, cholesterol, luteinizing hormone (LH), and insulin resistance were also reported. It is suggested that the benefits of quercetin may be more closely related to antioxidant and anti-inflammatory features. The authors suggest “quercetin could be considered as a potential agent to attenuate PCOS complications.”

In a randomized clinical trial, 84 PCOS patients were randomly assigned to two groups; the treatment group received 1 g quercetin (two 500 mg capsules) daily for 12 weeks and the control group received placebo. Oral quercetin supplementation improved the metabolic features of PCOS patients by increasing the expression and secretion of adiponectin and the AMP-activated protein kinase (AMPK) enzyme. (Adiponectin has been reported to be low in PCOS.)


Resveratrol Combined with Quercetin

Synergy between resveratrol and quercetin indicates that the two compounds together may be more beneficial than either one taken alone.

Overall, resveratrol and quercetin does not appear to have side effects and are well tolerated.  No major side effects were stated in long-term clinical trials. In fact, resveratrol has been found to be safe and well-tolerated at up to 5 g/day, either as a single dose or as fraction of multiple-day dosing schedule.


Resveratrol may decrease the effectiveness of certain medications, including blood thinners, cholesterol-lowering statins, immunosuppressive pharmaceuticals, and chemotherapeutic agents.


*FDA regulations strictly prohibit the use of therapeutic or medical claims in conjunction with the sale of any product not approved by the FDA. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*Individual results may vary. Take only as directed under the supervision of a Physician.

*The information and products presented on this website are not intended as a substitute for the advice or medical care of a qualified physician. No action should be taken solely on its content. You should not use the information on this web site for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment.

*PCOS Nutrition Center, LLC urges you consult with your physician or healthcare provider before starting or modifying any diet, exercise or supplementation program or any other therapy or lifestyle activity related to your health, including the advantages and risks of using of supplemental nutrition products.

*PCOS Nutrition Center, LLC does not imply or advocate the use of any nutritional supplement for any reason, other than to increase dietary intake levels of specific nutrients.

*PCOS Nutrition Center, LLC assumes no responsibility for the improper use of and self-diagnosis and/or treatment using these products. PCOS Nutrition Center, LLC products should not be used as a substitute for medically supervised therapy or as a substitute for prescription medications.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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