The 10 Best Supplements for PCOS

Here’s our list of the 10 best nutrition supplements for people with PCOS.

While no pill or drink can replace a healthy way of eating and lifestyle, emerging research has shown that taking the right dietary supplements can help to improve PCOS. That’s because people with PCOS have been shown to be deficient in some key vitamins and minerals, many of which affect fertility and insulin resistance. Certain medications are also known to affect the absorption of specific nutrients.

Vitamin D

Vitamin D is the first pick on our top 10 list of best supplements for PCOS because it plays an important role in the health and fertility for people with PCOS. Despite the importance, research shows that 67-85% of women with PCOS are deficient in vitamin D.

Recognized as a vitamin and a hormone, Vitamin D receptors have now been identified in almost every tissue and cell in the human body. This Vitamin has also been found to be involved in follicle egg maturation and development, making it a key vitamin women who are trying to conceive should consider supplementing with.

Vitamin D has been associated with reducing testosterone levels in women with PCOS. A review of six clinical trials with 183 women with PCOS revealed that vitamin D supplementation significantly reduced total testosterone levels.

Another study also found significant reduction in androgens in PCOS women. Both total testosterone and androgens levels were reduced (by 12% and 17%) after three months of supplementing with vitamin D 50,000 IU each month. All these reasons are why we picked vitamin D as one of the best supplements for PCOS.


Vitamin D for PCOS: The Key to A Healthy Pregnancy

pcos ultra D

Fish Oil

Omega-3 fats are essential for people with PCOS, as they provide numerous health benefits. Omega-3 fats are linked to improving triglycerides and insulin levels, lowering inflammation and blood pressure, and even providing better hair and skin quality and improving your mood. DHA is particularly important during pregnancy, as it aids in the baby’s brain development. New research shows omega-3 fats can even boost fertility in those with PCOS.

There are three different types of omega-3 fats: Alpha-linolenic acid (ALA) are plant based omega-3s found in avocados; nuts like walnuts and almonds; seeds like hemp, chia, and flax, and oils like olive and avocado oil. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are omega-3 fats found in egg yolks and fatty or “oily” cold water fish such as salmon, tuna, trout, and halibut. Few other fish are rich in omega-3s.

Fish and fish oil are the best ways to get in omega-3 fats. This is because only a small percentage of plant-based omega-3 foods like nuts and seeds, are converted into DHA and EPA in the body.

Nutrition guidelines recommend we consume cold-water or fatty fish two times per week to reap the benefits of omega-3 fatty acids. Salmon, halibut, tuna, and trout are the best sources of omega-3s. Even if you eat these types of fish twice a week or more, you may consider taking a fish oil supplement.




Myo and d-Chiro Inositol

Inositols top our list of 10 best supplements for PCOS. Inositols are relatives of B-vitamins. MYO and d-chiro inositol (DCI), are the two most common types that work differently in the body.

It’s believed that people with PCOS may have a defect in “secondary messengers” which relay signals of insulin, contributing to insulin resistance. MYO and DCI work as these secondary messengers.

Simply put: when we eat foods (mostly carbohydrates), they get converted into glucose in our blood stream. We need the glucose to enter our cells to be used for energy. When blood glucose levels rise, a signal (imagine a doorbell is rung) is sent from the cell door to the nucleus telling it to open up. However, with PCOS, the doorbell on the cell door may be defective. This means that it takes longer for the cells to open its doors to glucose resulting in higher amounts of insulin needing to be secreted. Secondary messengers acts to repair the doorbell so that the cell doors open in response to glucose, resulting in less insulin needing to be secreted.

Benefits of inositols include improved menstrual regulation and better egg quality. Inositols have also been found to improve insulin and cholesterol levels, help with acne, and even mood.

Supplementing with MYO and DCI in a 40:1 ratio is ideal to mimic this unique ratio in the body. This combination has been shown to work better than either MYO or DCI alone in PCOS. Ovasitol has this unique 40:1 ratio.


READ: 10 Surprising Benefits of Ovasitol for PCOS

Ovasitol for PCOS


N-acetylcystine (NAC) is helpful for improving fertility and many of the metabolic aspects related to PCOS such as fatty liver, high cholesterol and insulin resistance. NAC is also great for keeping the immune system healthy.

NAC is an antioxidant and amino acid. Specifically, it’s a derivative of the amino acid L-cysteine, an essential precursor used by the body to produce glutathione, an antioxidant that protects against free radical damage and oxidative stress and is a critical factor in supporting a healthy immune system.

A study published in the European Journal of Obstetrics, Gynecology, and Reproductive Biology compared the effects of NAC and metformin in women with PCOS. In this prospective trial, 100 women were divided to receive either metformin (500 mg three times daily) or NAC (600 mg three times daily) for 24 weeks. Both treatments resulted in significant and equal decreases in BMI, hirsutism, fasting insulin, free testosterone, and menstrual irregularity

Three randomized studies compared NAC or metformin with Clomid in women with PCOS. In two of the studies, Clomid plus NAC resulted in improved ovulation and pregnancy rates compared with placebo.




Like NAC, berberine works as an insulin-sensitizer and its potency has been compared with that of metformin. This herb is also an aggressive way to reduce high cholesterol levels and fatty liver.

Berberine slows the release of free fatty acids while boosting fat burning in the mitochondria to lower cholesterol levels. Berberine also inhibits the enzyme lipoprotein lipase which is responsible for producing cholesterol and triglycerides. Berberine has also been shown to promote cholesterol excretion from the liver to bile.


pcos berberine



pcos supplements


Magnesium is an important mineral that people with PCOS are significantly lacking in. Women with PCOS are 19 times more likely to have a magnesium deficiency, according to a study in Gynecology Endocrinology. This is concerning as magnesium has been shown to play a role in glucose, insulin, and blood pressure regulation.

Magnesium can also help prevent migraines and improve PMS symptoms as well as mood. A review of 18 studies published in Nutrients, showed that magnesium does have a beneficial effect for people with anxiety. Many symptoms of anxiety such as apathy, anxious behavior, anger, nervousness, insomnia, rapid pulse, or heart palpitations may be reduced by supplementing with magnesium.

Added bonus: Higher levels of magnesium can also help with sleep, which women with PCOS have difficulty with.


magnesium for pcos


Zinc isn’t typically on the radar for most people with PCOS but it should be! Studies are showing that women with PCOS have low levels of zinc. The good news is that increasing levels of zinc can improve many of the frustrating symptoms those with PCOS experience every day like acne, hair loss, and excessive hair growth. That’s because zinc works to inhibit the enzyme that converts testosterone into its non-aromatizable form, dihydrotestosterone (DHT).

Our PCOS MULTI® has been specifically formulated with higher amounts of zinc for this reason.


PCOS Multivitamin

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Co Enzyme Q10

Coenzyme Q10 or CoQ10, plays a role in energy production in muscle cells. Emerging research is showing that CoQ10, may offer numerous benefits to people with PCOS.  Coenzyme Q10 has been shown to be involved in improving fertility and pregnancy in women with PCOS by improving egg quality. Newer research is showing the potential of Q10 to lower cholesterol and insulin levels as well. Supplementing with CoQ10 is important if you take a statin as it affects the absorption of Q10.



coQ10 for pcos

Vitamin B12

Research is strongly showing that long-term use of metformin and at high doses (1.5mg or higher daily) can deplete levels of vitamin B12. A deficiency of vitamin B12 can cause permanent neurological and nerve damage as well as mood changes and decreased energy. There is evidence that a deficiency can occur just after 3 months of use.

Individuals who take metformin get B12 levels checked annually. A simple blood test can assess vitamin B12 status. Elevated serum homocysteine and methylmalonic acid levels (the best indicator) may also indicate a B12 deficiency.

Mandatory supplementation with B12 has now been proposed for those taking metformin. Taking a daily multivitamin containing 100% of the daily value (DV) for vitamin B12 may do the trick although many of our patients who take a mulitivitamin with B12 and are on high doses of metformin are still deficient in vitamin B12, requiring extra supplementation.

The best absorbable form of Vitamin B12 is methlycobalimum. Taking vitamin B12 sublingual (under the tongue) is recommended for over the counter B12 supplements.


7 Signs You’re Not Getting Enough Vitamin B12


Last on our top 10 list of best supplements for PCOS is Resveratrol. Resveratrol, a component of red wine and grapes, has been shown to offer numerous health benefits in helping to improve both metabolic and reproductive aspects in PCOS. Resveratrol has been known for anti-aging, anticancer, and cardioprotective properties. Rich in polyphenols and antioxidants, resveratrol has been shown to have the potential to fight inflammation as well as reduce cholesterol and insulin in other populations.

A randomized double-blind, placebo-controlled trial found that resveratrol (1,500 mg) over a period of 3 months led to a 23% reduction in total testosterone levels and 22% reduction in DHEA sulfate levels. The other good news was that women who were given resveratrol improved their insulin levels. In fact, fasting insulin levels dropped by a whopping 32% during the three-month study.

pcos to pregnant

Bottom Line:

In addition to a healthy lifestyle, taking supplements may help to improve PCOS symptoms and increase fertility. Taking them consistently is key for best results. Monitoring lab values as well as physical symptoms is also helpful to see if a supplement is beneficial. As always, please consult with your doctor before taking any dietary supplement.


  1. Thomson RL, Spedding S, Buckley JDVitamin D in the aetiology and management of polycystic ovary syndrome. Clin Endocrinol (Oxf). 2012 Sep; 77(3):343-50.
  2. Azadi-Yazdi M1, Nadjarzadeh A1, Khosravi-Boroujeni H. The Effect of Vitamin D Supplementation on the Androgenic Profile in Patients with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Clinical Trials. Horm Metab Res. 2017 Mar;49(3):174-179.
  3. Pal L, Berry A, Coraluzzi L, Kustan E, Danton C, Shaw J, Taylor H Therapeutic Implications of vitamin D and calcium in overweight women with polycystic ovary syndrome.. Gynecol Endocrinol. 2012;28:965–968.
  4. Oner G, Muderris II. Clinical, endocrine and metabolic effects of metformin vs N-acetyl-cysteine in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2011 Aug 8.
  5. Salehpour S, Akbari Sene A, Saharkhiz N, Sohrabi MR, Moghimian F. N-acetylcysteine as an adjuvant to clomiphene citrate for successful induction of ovulation in infertile patients with polycystic ovary syndrome. J Obstet Gynaecol Res. 2012;38(9):1182-1186.
  6. Abu Hashim H, Anwar K, El-Fatah RA. N-acetyl cysteine plus clomiphene citrate versus metformin and clomiphene citrate in treatment of clomiphene-resistant polycystic ovary syndrome: a randomized controlled trial. J Women’s Health (2002). 2010;19(11):2043-2048.
  7. Berberine improves insulin resistance in granulosa cells in similar way to metformin. Fertility and sterility.2006; supplement S459-S460.
  8. Li MF1, Zhou XM1,2, Li XL1,2The Effect of Berberine on Polycystic Ovary Syndrome Patients with Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review Fertility and ster Evid Based Complement Alternat Med. 2018 Nov 14;2018:2532935.
  9. Sharifi F, Mazloomi S, Hajihosseini R et al. Serum magnesium concentrations in polycystic ovary syndrome and its association with insulin resistance. Gynecol Endocrinol. 2012;28(1):7-11.
  10. Boyle NB, Lawton C, Dye L. The effects of magnesium supplementation on subjective anxiety and stress-A systematic review. Nutrients. 2017;9(5).
  11. Jamilian M, Foroozanfard F, Bahmani F, Talaee R, Monavari M, Asemi Z. Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. Biol Trace Elem Res. 2016 Apr;170(2):271-8.
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Comments (10)
  • Lisa Gardner

    December 21, 2020 at 10:14 am

    I have PCOS I grow hair on my face and I don’t ovulate I have periods every three to six months like to get back on the road with my health I’m tired have you seen tweezers all the time is there any way you can tell me the best septum for me for my pcsos all the time

  • Priya

    June 1, 2023 at 1:16 am

    Hi I’m interested in getting your supplements but I’m not sure what to take. I’m diagnosed with PCOS since my early 20s. I’m 43 this year and we have been trying for a baby for 12 years now. I was also diagnosed with type 2 diabetes 3 years ago. I have very terrible side effects taking metformin. As such I have stopped taking metformin. I am currently taking ovasitol together with Vit D 1000iu and folic acid 5mg. I’m also taking CoQ10. I am interested in getting your magnesium and zinc. But am comfused if I should get individual magnesium and zinc supplements separately or shall I get the prenatal vitamins since it contains all the necessary vitamins. Please advice so that I can make my purchase from you. Thank you

  • Angela Grassi

    June 1, 2023 at 12:14 pm

    Hi Priya, Thanks for contacting us. We recommend at least 4,000 IU vitamin D daily if TTC. Ovasitol and Coq10 are great for fertility. We would recommend a prenatal such as PCOS PRENTAL in our store as well as NAC. Here is a link to our preconception bundle:

    Let us know if you have additional questions. Angela does provide one-one nutrition coaching if you’re interested you can book a call with her to learn more:


    July 13, 2023 at 8:36 am

    Where to buy?

  • Angela Grassi

    July 28, 2023 at 4:30 pm

    All supplements are available in our PCOS Nutrition Center Supplement Store:

  • Danii Alca

    July 31, 2023 at 10:55 am

    Do you do international shipping? I’m interested in your products. I’ve been diagnosed with PCOS 2 years back.

  • Angela Grassi

    July 31, 2023 at 1:08 pm

    We do not ship outside of the USA or Canada directly. However, our customers have had success getting orders shipped to them internationally through a 3rd party shipper called Stackry.
    Here is how:
    Step 1: Create a FREE account on Stackry here (there is a fee that varies between countries)
    Step 2: Receive your US-based shipping address
    Step 3: Go to our checkout page and enter with your US-based shipping address
    Step 4: Stackry will provide you with a tracking # so you can track your supplement delivery!

  • Cathy

    August 2, 2023 at 12:38 am

    Does this help with engergy levels

  • Angela Grassi

    August 9, 2023 at 9:38 am


  • Peace

    October 13, 2023 at 7:32 am

    Very good

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